1. Frieza: Destructive Ability Frieza, the potential God of Destruction of Universe 7, has had a love for destruction since he was young. His power level on Planet Namek was nearly 600,000, far surpassing Vegeta's power level of only 20,000. Frieza could easily annihilate planets with a single energy ball, as demonstrated by the destruction of Vegeta's home planet.

2. Cell: Infinite Stamina Cell achieved his perfect form by absorbing Androids 17 and 18. Even under the pressure of Super Saiyan 2 Gohan, Cell self-destructed but returned even more powerful due to the Saiyan cells within him. He effortlessly defeated Trunks and severely injured Gohan's left arm. Cell even had the upper hand against Gohan's Kamehameha with his version. However, Gohan ultimately defeated him with his full power, inspired by Goku's encouragement.

3. Buu: Infinite Regeneration Ability Buu possesses the power of infinite regeneration. As long as even one cell remains, he can fully regenerate. He can also absorb others and integrate them into his own body. It is incredibly difficult to kill him unless his power is completely obliterated. 

These three main antagonists in the Dragon Ball series each possess formidable abilities. Frieza possesses immense destructive power, Cell has infinite stamina, and Buu has infinite regeneration.